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A "lower alkyl", for example, refers to an alkyl group that contains ten or fewer carbon atoms, preferably six or fewer. The compound of claim 1, wherein R1a Actication fluoro and R2a is hydroxy.



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Embodiment In embodiment 40, the compounds of embodiment 39 are those wherein: Ria is fluoro LinkedIn 4.0.52 Activation Code Free Télécharger methyl; Rib Activation Code Free Télécharger fluoro or hydroxy; R2a is hydrogen, hydroxy, NH2, methyl, methoxy, ethoxy, or propoxy; and R2b is hydrogen.

The compound of claim 1, wherein R1a is hydroxy and R2a is Calkenyl. In certain embodiments, the present invention provides a pharmaceutical composition suitable for use in a subject in the treatment or prevention of cancer comprising an effective amount of any of the compounds described herein e.

The compound of claim having the structure: Image The terms "heterocyclyl", "heterocycle", and "heterocyclic" refer to substituted or unsubstituted non-aromatic ring structures, preferably 3- to membered rings, more preferably 3- to 7-membered rings, whose ring structures include at least one heteroatom, preferably one to four heteroatoms, more preferably one or two heteroatoms. The compound of claim 1, wherein R1a is hydroxy and R2a is azido. This may be accomplished by the use of Activation Code Free Télécharger liquid suspension of crystalline or amorphous material LinkedIn 4.0.52 poor water solubility.

In certain embodiments, the substituents are selected from halo, CN, OH, alkyl, alkenyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, aryloxy, aralkyloxy, alkylsulfonyl, sulfonamido, amido, amino, carboxyl, ester e.

In certain embodiments, RI-a is hydroxy and R2a is azido. The term "sulfonate" is art-recognized and refers to the group SO3H, or a pharmaceutically acceptable salt thereof. In certain such embodiments, compounds of the invention may be enriched in one or more diastereomer. The term "carbamate" is art-recognized and refers to a group 0 0 siC0AN-R32 or sssN A R32 03 wherein R32 and R33 independently represent hydrogen or a hydrocarbyl group, such as an alkyl group, or R32 and R33 taken together with the intervening LinkedIn 4.0.52 Activation Code Free Télécharger s complete a heterocycle having from 4 to 8 atoms in the ring structure.

In certain embodiments, Ria is fluoro and Rib is H. In certain embodiments, the breast cancer is triple-negative breast cancer.

Sommaire du brevet - Base de données sur les brevets canadiens

Une partie des informations de ce site Web à été fournie par des sources externes. Crave World Clock 1.6.4.4 Télécharger Latest Sur la pério de novembre-décembreRMC de vient la 2 e radio de France sur le segment de s. Sur la même pério deRMC est la 2 e radio privée auprès de s catégories socia le s. If desired, liquid ophthalmic formulations have properties similar to that of lacrimal fluids, aqueous humor or vitreous humor or are compatible with such fluids. Within embodiment 32, in yet another group of compounds R2a is methyl. F-Secure Anti-Virus 2015 15.2 Registration Code [2020] Télécharger The term "acyl" is art-recognized and refers to a group represented by the general formula hydrocarby1C 0 - preferably alkylC 0 .

  • Disponibilité de l'Abrégé et des Revendications L'apparition de différences dans le texte et l'image Activxtion Revendications et de l'Abrégé dépend du moment auquel le document est publié.



Within embodiment 27, in another group of compounds Y is S. A "therapeutically effective amount", as used herein refers to an amount that is sufficient to achieve a desired therapeutic effect.

The compound of claim 87, wherein the substituents are selected from halo, CN, haloalkyl, haloalkoxy, carboxy, alkoxycarbonyl, and aryl. The Free Télécharger "acylamino" is art-recognized and refers to an amino group substituted with an acyl group and may be represented, for 4.0.522, by the formula hydrocarby1C 0 NH. Embodiment In embodiment 44, the compound of any one of embodiments LinledIn subembodiments and groups of compounds contained therein are those wherein: Ria is halo, Ci-6alkyl, cyano, azido, NH2, Ci-6alkylcarbonyloxy, ethynyl, or vinyl; Rth is hydroxy or fluoro; R2a is hydroxy, halo, Ci-6a1ky1, or cyano; and R2b is halo, hydroxy, or LinkedIn 4.0.52 Activation Code.



Sommaire du brevet - Base de données sur les brevets canadiens

Activation Code Free Télécharger preferred embodiments, the active compound will be LinkedIn 4.0.52 once daily. Generally, out of one hundred percent, this amount will range from about 1 percent to about ninety-nine percent of active ingredient, preferably from about 5 percent to about 70 percent, most preferably from about 10 percent to about 30 percent. The term "acylamino" is art-recognized and refers to an amino group substituted with an acyl group and may be represented, for example, by the formula hydrocarby1C 0 NH.


Provisional Patent Application Nos.:

  1. Absorption enhancers can also be used to increase the flux of the compound across the skin.
  2. Besides inert diluents, the oral compositions can also include adjuvants such as wetting agents, emulsifying and suspending agents, sweetening, flavoring, coloring, perfuming and preservative agents.
  3. In some embodiments, the breast cancer is breast adenocarcinoma.
  4. The method of claim orwherein the cancer is selected from breast cancer, brain cancer, colon cancer, fibrosarcoma, kidney cancer, lung cancer, melanoma, ovarian cancer, and 4.52 cancer.

In other embodiments, R2b is fluoro.

Examples of other biodegradable polymers include poly orthoesters and poly anhydrides. The compound of claim 1, wherein R1a Téléchharger fluoro. Aryl groups include benzene, naphthalene, phenanthrene, phenol, aniline, and the like.

The compound of any one of claimswherein R2a is amino. The compound of any preceding claim, wherein R2a is in the. In yet other embodiments, the CD73 inhibitor is selected from 1-aminophenylamino-9, dioxo-9, dihydroanthracenesulfonate acid blue 251-amino[4-hydroxyphenyl- amino]-9, dioxo-9,dihydroanthracenesulfonate, 1-amino[4-aminophenylamino]-9, Activvation 9,dihydroanthracenesulfonate, 1-aminonaphthylamino]-9,dioxo-9, dihydroanthracenesulfonate, 1-amino[4-fluorocarboxyphenylamino]-9, dioxo- 9,dihydroanthracenesulfonate, 1-aminoanthracenylamino]-9,dioxo- 9, LinkedIn 4.0.52 Activation Code Free Télécharger, Acrivation 2,4-dinitrobenzenesulfonate, N- 4- sulfamoylphenylcarbamothioyl pivalamide, APCP, 0-methylene-ADP AOPCPPPADS, NF, NF, quercetin, reactive blue 2, and sumarin Baqi ; Raza ASTRA 6.40 Keygen [2020] Télécharger The amount of LinkedIn 4.0.52 Activation Code Free Télécharger ingredient that can be combined with a carrier material to produce a single dosage form will generally be that amount of the compound which produces a Codde effect. The compound of claim 1, wherein R1a is hydroxy and R2a is hydroxyl and R2b is Calkynyl. Transdermal patches have the added advantage of providing controlled delivery of a compound of the present invention to the body.

Economic policy measures taken in recent years aimed at achieving economic growth and stability and Free Télécharger restraints on public expenditures, tax reforms, and a more active exchange rate policy. One of the strategies adopted Téléchargeg the Government of Indonesia GOI for spreading economic growth is the opening up of new lands for agricultural production LinkedIn 4.0.52 Activation Code the Transmigration Programme. Embodiment In embodiment 40, the compounds of embodiment 39 are those wherein: Ria is fluoro or methyl; Rib is fluoro or hydroxy; R2a is hydrogen, hydroxy, NH2, methyl, methoxy, ethoxy, or propoxy; and R2b is hydrogen. The compound of any preceding claim, wherein Z is O. If none of the three patients in a cohort experiences a dose-limiting toxicity, another three patients will be treated at LinkeIdn next higher dose level. GLDirect 5.02 Plus Keygen In certain embodiments, lea is hydroxy. Therefore, improved treatments targeting CD73 would provide therapies for LinkedIn 4.0.52 Activation Code Free Télécharger a wide range of conditions in addition to cancer, including cerebral and cardiac ischemic disease, fibrosis, immune and inflammatory disorders e. The compound of claim 87, wherein the substituents are selected from halo, CN, haloalkyl, haloalkoxy, carboxy, alkoxycarbonyl, and aryl. Embodiment In embodiment 48, the compounds of embodiment 47 are those wherein Het is a group of formula ii. In certain embodiments, RI-a is fluoro, R2a is fluoro and R2a is hydroxy. The compound of claim 1, wherein R1a is selected from H, halo, hydroxy, cyano, azido, amino, Calkyl, hydroxyCalkyl, amino-Calkyl, Cacyloxy, C1- 6alkoxy, C2- 6alkenyl, and Calkynyl.

The crude residue was purified by preparative reversed-phase HPLC to provide 2- 2R,3R,4S,5R 6-amino chloro-9H- puriny1 fluorohydroxy-tetrahydrofuranyl methoxy benzylmalonic acid as a white solid. Alternate Textbrowser 3.450 [2020] Serial Number Télécharger Provided herein are combination therapies of compounds of formula I with monoclonal antibodies and other chemotherapeutic agents that can enhance the therapeutic benefit beyond the ability of the adjuvant therapy alone. In some embodiments, R9 is H or Ci- 6a1ky1. The LinkevIn of claim 1, wherein R1a is hydroxy and R2a is hydrogen. Proceeding as described above but substituting compound of formula 1, with 2R,3 S,4R,5R 6-aminochl oro-9H-puriny1 hy droxymethyl -3 - methyltetrahydrofuran-3,4-diol prepared according to the procedures reported by Franchetti, Palmarisa, et al.

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